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M94A2944.TXT
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1994-10-25
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Document 2944
DOCN M94A2944
TI Preferential depletion of rectal lamina propria CD4+ lymphocytes.
DT 9412
AU Clayton F; Reka S; Kotler DP; St. Luke's/Roosevelt Hosp Ctr, New York,
NY 10025.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):189 (abstract no. PB0185). Unique
Identifier : AIDSLINE ICA10/94369631
AB OBJECTIVE: To compare changes in mucosal lymphoid populations during
disease progression. METHODS: We performed quantitative histologic and
immunohistochemical stains in 61 subjects; 7 with CD4 > 500 (Early), 24
with CD4 < 500 (Middle), 23 AIDS (Late), and 7 controls. Frozen rectal
biopsies had stains for T and B lymphocytes, macrophages, and
immunoglobulins, plus histopathology. RESULTS: The percentages and
numbers of CD4 in lamina propria (LP) were decreased in Early, compared
in lymphoid aggregates (LA) and blood (PBL), while CD8 percentages and
numbers rose during disease progression. B lymphocytes, macrophages, and
plasma cells did not vary. DISCUSSION AND CONCLUSIONS: There is
preferential depletion of CD4 from LP during disease progression. As LP
CD4 are memory cells while LA CD4 are naive cells, the results could
reflect differences in susceptibility to infection or lysis. The early
loss of LP CD4 could promote immunoregulatory defects. TABULAR DATA, SEE
ABSTRACT VOLUME.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY
B-Lymphocytes/IMMUNOLOGY/PATHOLOGY Biopsy Human
Immunoglobulins/METABOLISM Intestinal Mucosa/*IMMUNOLOGY/PATHOLOGY
Leukocyte Count Macrophages/IMMUNOLOGY/PATHOLOGY
Rectum/*IMMUNOLOGY/PATHOLOGY T-Lymphocytes/IMMUNOLOGY/PATHOLOGY T4
Lymphocytes/*IMMUNOLOGY/PATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).